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The drug had a half-life of about one week and stronger effects on glycaemia and body weight with mean reductions in HbA 1c of 18 mmol/mol and in body weight of 5.7 kg in the phase-III programme [20]

Retatrutide is studied in research settings as a triple glucagon / GIP / GLP-1 receptor agonist, with interest in multi-incretin signaling, energy-expenditure models, food-intake models, glycemic endpoints, and body-composition research

38 In a healthy human, ~70% of the cells in a pancreatic islet of Langerhans, are beta-cells, 20% are alpha-cells, and the remaining 10% consist of (in order of most to least prevalent) delta, gamma and epsilon cells

Hristakeva, S., Liaukonyt, J., & Feler, L