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Severe vitamin B 12 deficiency in a mouse model showed dramatic alterations in the level of DNA methylation in the brain, which might lead to neurologic impairments (103)
However, with the implementation of stringent sourcing controls, advanced hydrolysis processes, and regulatory guidelines governing animal-derived materials, current assessments indicate that the residual risk of prion transmission is considered very low when collagen peptides are manufactured in compliance with established standards [91]
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