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The combination of glucagon's direct hepatic effects and GLP-1's metabolic effects makes dual agonists generally superior to pure GLP-1 agonists for hepatic steatosis, supporting potential MASH indications for mazdutide in future regulatory submissions

For instance, women with darker skin, as more melanin reduces vitamin D synthesis, or those who get little sun exposure should be extra vigilant about supplementation

In addition to a medium made of 0.5 ml of DMEM, 10% FBS, 100 U/mL of penicillin, and 100 mg/mL of streptomycin, BPC 157 was added to each well in concentrations of 0 (control group), 0.1, 0.25, and 0.5 ug/mL for 1, 2, and 3 days in a humidified atmosphere