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We found that depletion of KG using either an IDH1 inhibitor ( Fig

Black Pepper fruit extract 10:1 5 mg: May enhance absorption and bioavailability of other nutrients

To test whether this newly identified L1FnIII-2 interaction is functionally important for receptor activation, we introduced multiple mutations in the L1 hairpin of IGF1R (K164A, T166A, N169A, and Y171A), deleted the entire L1 hairpin (163174), or replaced this L1 hairpin with a short GSGS loop (163GS) to disrupt this interaction