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One important feature may be neurogenic claudication which is the onset and worsening of pain, weakness, numbness, tingling, heaviness, or fatigue sensation in the hips, buttocks, and lower limbs that is exacerbated with standing and walking, and improved with sitting or leaning forward on an object such as a shopping cart or walker
Systemic intravenous (IV) as well as local administration of manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) displays no detectable toxicity while offering protection from irradiation-induced damage
Most protocols run 4 to 6 weeks minimum, with some extending to 8 to 12 weeks for more severe injuries
Microcirculation 3:129247
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