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The magnitude of initial weight loss reported in trials with retatrutide approached the ones seen after bariatric surgery, such as in Roux-en-Y gastric bypass surgery, in which an average net weight loss of 35 % was reported by a meta-analysis during the first few post-surgical years [29]

Retatrutide-Specific Considerations The Phase 2 trial for retatrutide reported higher rates of gastrointestinal side effects at upper dose levels compared to tirzepatide, which may be attributed to the additional glucagon receptor activation

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