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Reported side effects Mild headache or fatigue typically transient during initial use Mild gastrointestinal discomfort reported in some oral formulation users Sleep disruption or irritability potential sign of overstimulation Theoretical safety concerns Critical note: Because Dihexa activates the HGF/c-Met pathway which promotes cellular growth and repair there is a theoretical concern that it could potentially stimulate unwanted cell proliferation in individuals with active cancer or high cancer risk

Although previous studies have shown no clear correlation between the GSTP1 status and the clinicopathological characteristics of PCa, GSTP1 methylation is associated with a more aggressive ER-positive breast cancer phenotype (95)

(138) reported comparable results using Artemisia aucheri phenolic compounds encapsulated in nanoliposomes to treat C

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