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Figure 1 The L-cells derived cocktail of hormones is believed to play pivotal roles in digestion, for example slowing down the GI motility (PYY) and suppressing the appetite in vivo (GLP-1, oxyntomodulin, PYY), apparently in response to direct sensing of the gut luminal content via G-protein coupled receptors or through neuronal circuits (43, 52)

By engaging multiple pathways, tirzepatide influences how the body responds to food intake and energy use

Research into efficient viral and non-viral delivery systems will be essential to advancing these therapies

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