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Consistently, NAD + deficiency leads to an impaired DDR and an increased genomic instability, suggesting an interplay between genomic stability and NAD + metabolism

Biomaterial-based delivery systems (hydrogels) have been shown to be excellent carriers that enhance cell/drug localization, survival and therapeutic efficacy in organ injury repair

Adenylyl cyclase is activated at the intracellular face

Acknowledgements This work was supported by the Ministry of Education, Spain (Grant number PRX18/00245) while R.Muga was Visiting Scholar with Professor A