retatrutide grey and the Market: Buyer Beware – Sarah Hormachea Vial of unapproved peptide retatrutide

Food and Drug Administration, FDA, 8 Nov

This hormone helps boost insulin secretion (when glucose levels are high) and insulin sensitivity, enhances fat metabolism, and improves energy balance, leading to greater weight loss than single receptor drugs such as semaglutide (Ozempic and Wegovy), liraglutide, and dulaglutide

Losing weight that includes a large proportion of muscle might result in a smaller number on the scale but may not lead to the desired firmer, more "toned" appearance

In addition to providing coverage of these drugs for obesity, which would be a new indication in Medicare and in most states under Medicaid, these efforts will also allow beneficiaries in participating states and Part D plans to access GLP-1s for obesity at a lower out-of-pocket cost than if they were to purchase them with cash at the direct-to-consumer prices offered by the manufacturers