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Common experiences: Nausea peaks (may be present most mornings) Reduced food intake due to appetite suppression and nausea Some participants experience vomiting Fatigue from rapid caloric reduction Weight loss: Typically 8-12% cumulative by end of month 2 Management priority: Push through this period

We dig into the wider class in our article on whether GLP-1 medications reduce alcohol cravings, and we look at a closely related medication in our piece on tirzepatide and alcohol cravings

Selenoprotein P protects endothelial cells from oxidative damage by stimulation of glutathione peroxidase expression and activity

This effect not only directly influences the abundance of IBD-related gut microbiota but also helps gut microbiota to produce short-chain fatty acids (SCFAs), regulators of T lymphocytes, macrophages, and neutrophils, contributing to gut homeostasis (167170)