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People who had previously used gastrointestinal medicationspotentially suggesting they're more vulnerable to the common adverse gastrointestinal side-effects reported by GLP1-RA users like nausea, vomiting, and diarrheawere 9 percent more likely to discontinue semaglutide within the first year

This means that patients will need to also be following a strict, calorie deficient diet that has been recommended by either their physician or another specialist, and should also be integrating regular exercise into their normal routine

CEO David Ricks highlighted progress on orforglipron, an oral GLP-1 candidate that completed four Phase 3 trials and could enable global obesity submissions by year end

Diabetes, Obesity and Metabolism , 27 (3), 1601-1604