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Liraglutide should be used with caution if the patient has a history of thyroid cancer or a family history of medullary thyroid cancer as adverse effects, such as goitre, have been reported in trials, particularly in patients with pre-existing thyroid disease[11]

SGLT-is significantly reduce the risk of HF by 3040% in individuals with T2D with established or high risk of CVD according to previous large-scale RCTs, and the HF benefits exists no matter the ejection fraction is preserved or reduced