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PARP-1 contributes significantly by selectively binding to cisplatin-induced DNA damage, particularly 1, 2-d(GpG) crosslinks ( Table 4 )

Quick Answer: Tirzepatide may cause tiredness in some patients, though fatigue is not listed among the most common side effects in clinical trials, with indirect mechanisms like reduced caloric intake and gastrointestinal effects potentially contributing to this symptom

If your FIB-4 score suggests possible advanced fibrosis, your GP may arrange an Enhanced Liver Fibrosis (ELF) blood test

The upregulation of NRF2 and SOD1, along with the activation of ROS scavenging pathways, can lead to resistance to chemotherapy or targeted therapy in various tumors