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Low plasma insulin-like growth factor-1 levels are associated with reduced insulin sensitivity and increased insulin secretion in nondiabetic subjects

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[Note: RBCs are totally dependent on the pentose phosphate pathway for their supply of NADPH because, unlike other cell types, RBCs do not have an alternate source for this essential coenzyme.] Additional enzymes, such as superoxide dismutase and catalase, catalyze the conversion of other reactive oxygen intermediates to harmless products (see Figure 13.5B)