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A composite control group containing equal amounts of these three antihyperglycemics was also included, as was a control group of individuals who continued with their non-GLP-1RA antihyperglycemic regimen without additional new therapy (usual care)

It is also used to support weight loss in eligible adults with a BMI of 30 or higher, or 27+ with related health conditions

By combining genome-wide DNA methylation profiling, transcriptomic analysis, and untargeted metabolomics in subcutaneous adipose tissue, we found a regulatory role for AKT1, linking epigenetic deregulation to mitochondrial dysfunction and metabolic reprogramming

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