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Dihexa is reported to be active at picomolar concentrations in synaptogenesis assaysapproximately 10,00010,000,000-fold more potent than BDNF (brain-derived neurotrophic factor) in some in vitro measures, though this comparison involves different assay conditions and should not be taken as a direct clinical equivalence claim

GSH reductase (requires riboflavin as a co-factor) regenerates reduced-GSH from its oxidized disulfide (GSSG)

Interventions aimed at restoring redox balance, chelating iron, or directly inhibiting ferroptosis-related enzymes may offer novel strategies for renal protection in diabetic patients

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