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These minor gene effects could be detected by studying a much larger sample size

Clin Neuropharmacol 36:103106 Remington R, Lortie JJ, Hoffmann H, Page R, Morrell C, Shea TB (2015) A nutritional formulation for cognitive performance in mild cognitive impairment: a placebo-controlled trial with an open-label extension

Months six through nine: peak shedding and early recovery For most patients, shedding peaks around months four through seven and then gradually diminishes