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While these results are promising, the sample sizes are very small, and further studies are warranted to support these findings

Third, the TRIUMPH-4 population (obesity plus knee OA) is slightly different from the STEP-1 and SURMOUNT-1 populations (general obesity), so the definitive head-to-head comparison waits for TRIUMPH-1

Otherwise, the new GLP-1 medications may be a better choice since you can stop the medication. Do people need to focus on nutrition while taking weight-loss drugs

In 2023, the FDA and European Medicines Agency (EMA) began investigating a possible relationship after receiving reports of suicidal thoughts while patients were taking the drugs