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Dihydrotestosterone (DHT), an active metabolite of the major circulating androgen testosterone, induces partial apoptosis in androgen-sensitive hepatocytes (such as SMMC-7721 and L02 cells) via the PKR/eIF2/GADD153 cascade

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and licensed by Lilly, orforglipron opens the door to a new generation of incretin-based therapies more accessible, manufacturable, and globally deployable

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