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Berberine alone causes diarrhea in 15 to 25% of users at 1000 to 1500mg daily and gastrointestinal discomfort in up to 35% in clinical trials

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Schafer ST, Mansour AA, Schlachetzki JC, Pena M, Ghassemzadeh S, Mitchell L, et al

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Use of GLP-1 agonists for weight loss compared with use of bupropion-naltrexone was associated with increased risk of pancreatitis, gastroparesis, and bowel obstruction, according to a study in the JAMA medical journal

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