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Its well-known adverse events, e.g., interstitial pulmonary fibrosis, seizures, liver veno-occlusive disease, or sinusoidal obstruction syndrome [96] seem to be caused by glutathionyl-tetrahydrothiophene, a metabolite that derives from the irreversible GSH conjugation [97,98]

The p62/SQSTM1 (sequestosome 1) protein, which acts as a cargo receptor for autophagic degradation of ubiquitinated proteins, is up-regulated by various stressors

This might explain why some people dont experience immediate results from oral supplements alone

Importantly, the increase in the levels of these critical regulatory proteins occurred in the absence of any significant weight loss and calorie restriction 15