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Storing it colder may risk freezing, and warmer temperatures will accelerate degradation.

4 Effect sizes of age at treatment initiation on weight loss amongst GLP1-RA users across studies by ancestries

In order to work effectively, the NOS enzyme requires a cofactor molecule called BH4 ( tetrahydrobiopterin )

In clinical trials, semaglutide (Wegovy) averaged about 14.9% of body weight over 68 weeks in the STEP 1 trial, and tirzepatide (Zepbound) averaged about 20.9% at the highest studied dose in SURMOUNT-1