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When a prior authorization is denied, the practice can file an internal appeal, request a peer-to-peer review, or request external independent review for urgent cases

However, sequential exclusion of these trials resulted in only modest changes in pooled HRs and corresponding CIs, with no substantial shifts in the direction of effect, significance, or overall interpretation of the primary findings (Supplementary Figures S5S9)

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"With anything that you're taking, whether it's an FDA-approved product or a supplement, you always have to weigh the risk versus benefit," says the institute's president Rita Jew