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A 2025 study in JAMA Network Open found that people with type 2 diabetes who took semaglutide (Ozempic) or tirzepatide (Mounjaro) had a 76% higher risk of developing a rare condition called nonarteritic anterior ischemic optic neuropathy (NAION)

Moreover, there is now substantial evidence to show that the prediabetic state of impaired glucose tolerance (IGT) is itself a significant CVD risk factor [3, 4]

Sedation and tiredness were commonly reported with drugs targeting the opioid receptors (like naltrexone) and combination therapies that target both the opioid and monoamine systems (such as Contrave)