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Piezo1 was verified to be a key mediator of ferroptosis in TMC
GPX4: Glutathione Peroxidase 4, GSH: glutathione, ROS: reactive oxygen species, IL-6: Interleukin-6, Interleukin-1 beta, TNF-: Tumor Necrosis Factor-alpha, MDA: malondialdehyde, TCL6: T-cell Leukemia/Lymphoma 6,TFRC: transferrin receptor, ALKBH5: AlkB Homolog 5, RNA, demethylase, FTL: ferritin light chain, SLC7A11: Solute Carrier Family 7 Member 11, ACSL4: Acyl-CoA, Synthetase Long Chain Family Member 4, HUVECs: Human Umbilical Vein Endothelial Cells, BaP: Benzo[a]pyrene, MARCHF1: Membrane Associated Ring-CH-Type Finger 1, VEGFA: Vascular Endothelial Growth Factor A, ANG-1: Angiopoietin-1, IGF2BP3: Insulin-like Growth Factor 2 mRNA-binding Protein 3, lnc-HZ06: Long Non-coding RNA HZ06, HIF1: Hypoxia-inducible Factor 1-alpha, NCOA4: Nuclear Receptor Coactivator 4, CRY2: Cryptochrome Circadian Regulator 2, BMAL1: Brain and Muscle ARNT-Like 1, TP53: Tumor Protein p53, EZH2: Enhancer of Zeste Homolog 2, TIMP1: Tissue Inhibitor of Metalloproteinases 1, SLC3A2: Solute Carrier Family 3 Member 2, GABARAPL2: GABA, Type A Receptor-Associated Protein Like 2, Fer-1: ferrostatin-1
Under conditions of oxidative stress, the mitochondrial electron transport chain becomes less efficient, leading to increased production of superoxide radicals [86]
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