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Our focus was on the second-generation principal component-derived epigenetic clock, PCGrimAge 36,37 , a measure of biological aging that incorporates DNA methylation-based estimates of biomarkers associated with age-related mortality risk, the third-generation clock, DunedinPACE 37 , a measure of the pace of aging crucial for understanding the impact of interventions on epigenetic aging, and Lus telomere length predictor based on 140 CpGs 38

However, many patients find that fatigue improves significantly after the first 48 weeks as their body adapts to the medication and they establish sustainable eating and hydration patterns

Ive lost 45 pounds already

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