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A systematic review found FAE to have the longest persistence of treatment for non-biologic systemic therapies for psoriasis, showing discontinuation at a mean of 50.0 months, compared to methotrexate treatment discontinuation at 22.3 months

PubMed Khavinson VK, Razumovsky MI, Trofimova SV, et al

Like most supplements, these products arent FDA-regulated , so they dont go through the same testing for safety, quality, or results as prescription medications meaning theres no real proof they work or that they even contain the ingredients they claim to

Plant-derived metabolites like andrographolide have been shown to decrease microglial activation and inhibit -synuclein induced neurotoxicity