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The model of the open state conformation was based on the cryo-EM structure of GLP-1GLP-1RGs (PDB: 5VAI) and the Fab7F38ECD complex of the Fab7F38GLP-1R crystal structure presented here, which were superimposed on their ECDs using PyMOL

Identification of transcriptional targets during pancreatic growth after partial pancreatectomy and exendin-4 treatment

Most new moms in the study who used a GLP-1 drug mostly semaglutide were overweight before becoming pregnant and only 23% had diabetes, suggesting they primarily used the medication for weight loss, the authors wrote

This method was deemed appropriate given the nature of the dataset and the retrospective design of the study