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Then, GS-THT + is metabolized via a -elimination reaction to obtain -glutamyl-dehydroalanyl-glycine (EdAG), which reacts with a second GSH to form lanthionine GSG, a non-reducible analogue of GSH

Taken together, these data demonstrate that CYP-driven bioconversion of APAP occurs in our model and augments mortality, thus recapitulating similar findings described in vertebrate models 31

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Consistency of Application: This is often the most critical variable