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For six subjects, baseline GSH peaks were undetectable

This can lead to: Increased oxidative stress and cellular damage Impaired liver function and detoxification Greater risk of lung inflammation and asthma development Weakened immune response , making it harder to fight off illness A major International Study of Asthma and Allergies in Childhood (ISAAC) involving over 322,000 children across 50 countries found a strong exposure-dependent relationship between acetaminophen use and the development of asthma, rhinoconjunctivitis, and eczema

Ochsner J

However, when administering a lower dose of 2APB, i.e., 1 mg/kg, the protective effect on APAP tolerance was observed only in wild-type mice, for which survival rate was 100% at 60 h post-2APB administration