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Together, these studies highlight the complex interplay between CKD, neuroinflammation, and gut-derived signals, providing strong evidence that the gut microbiota and its metabolites play a significant role in promoting neuroinflammatory processes in CKD, which in turn contribute to cognitive decline and neurodegenerative changes
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Figure 1 demonstrates the correlation between the ability to cross the BBB and the neuroprotective effects of drugs
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