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This dual mechanism enhances insulin secretion and reduces hyperglycemia more effectively than treatments targeting only the GLP-1 receptor, contributing to significant weight loss and improved metabolic health

Stratified by lifestyle intervention Continuation of lifestyle interventions after treatment discontinuation may affect the extent of weight regain

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This portion of BCKDH is present on the endoplasmic reticulum (ER) and interacts with AMP deaminase 3 (AMPD3), and is negatively regulated by AMPD3