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It is important to note that the positive health impact of the MeD derives from the synergy of bioactive compounds and nutrients that interact with each other, producing increasing beneficial effects, which cannot be replicated by pharmacologically supplementing a single component [15, 62, 175, 190]

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Although an older study of perfused rabbit hearts showed no reduction in the damage caused by reperfusion following ischaemic insult (86) , more recent work in diabetic rats showed that 6 weeks of ergothioneine supplementation resulted in decreased biomarkers of cardiac injury, lipid peroxidation and inflammation (87)