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There is a research first demonstrating that ISL suppressed the cell cycle transition and inhibited the proliferation and migration of Hep3B cells in vivo and in vitro by suppressing cyclin D1 and PI3K/AKT pathway (Huang et al., 2020)

PMID: 35358930 J Pharm Anal A highly efficient protein corona-based proteomic analysis strategy for the discovery of pharmacodynamic biomarkers