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SmMYB98 can directly bind to the promoters of the key enzyme genes ( SmGGPPS1 ) in the terpene biosynthesis pathway and encoding phenylalanine ammonia lyase ( SmPAL1 ) and encoding rosmarinic acid synthase ( SmRAS1 ) in the phenolic acid biosynthesis pathway, directly regulate their expression levels and promote the synthesis of tanshinone and salvianolic acid (Hao et al., 2020)

Allosteric modulators Allosteric modulators typically attach to regions distinct from the orthosteric site of receptors, inducing conformational changes to regulate the affinity and/or efficacy of orthosteric ligands, or to directly modulate receptor activity with positive, negative, or neutral effects

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Its epidemiology shows marked geographic variation: incidence is highest in North America and Western Europe (920 cases per 100,000 person-years) but is rising rapidly in regions historically considered low risk, including parts of Asia and South America (Hracs et al., 2025