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Pre-osteoblastic cell lines with MC3T3-E1 as a prominent example, offer a more uniform and stable population of immortalized cells suitable for studies of bone tissue engineering ( Although not as prominently as in the case of primary stem cells, pre-osteoblastic cell lines such as MC3T3 and NH3T3 possess a certain degree of osteogenic capacity which can be regulated by the redox environment

Pregnancy and Lactation Limited safety data exists for glutathione supplementation during pregnancy

Skeletal unloading causes resistance of osteoprogenitor cells to parathyroid hormone and to insulin-like growth factor-I