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Existing guidelines may be challenged if new and stronger research data emerge that suggest potential risks during pregnancy and child development

In human growth-hormone-deficiency trials using recombinant native IGF-1 (mecasermin, brand name Increlex), the approved dose range is 0.04-0.12 mg/kg twice daily by subcutaneous injection, titrated to IGF-1 levels in the age- and sex-normalised reference range [15]

(2015) 112:E15665

Unlike traditional prohormones that require cycling, Andriol can be taken year-round without interruption, necessitating a post-cycle therapy (PCT) only upon discontinuation