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This is why retatrutide produces higher GI rates than its dual-agonist predecessor tirzepatide

While researchers have explored its potential for neurological and metabolic conditions, the clearest clinical benefits are in liver health.4 6 7 Doses as low as 250mg/day have shown modest improvements in some liver studies, but 500mg/day is the minimum dose that consistently produces meaningful benefits.41 In patients with primary biliary cholangitis (PBC), 500mg/day lowered key liver enzymes linked to inflammation and damage.9 There is evidence that higher doses often perform better

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