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On the oral small-molecule front, Ascletis reported placebo-adjusted weight reductions of 5.4 percent to 7.7 percent at 13 weeks in a US Phase 2 study, with no plateau in weight loss observed

The consequences extend beyond simple fatigue: B12 deficiency can trigger mood disturbances, cognitive decline, nerve damage, and compromised immune function

Growth Hormone Some animal research associated DSIP with slow-wave sleep and sleep-related growth-hormone release

Competing Interests Professor Melanie Davies has acted as a consultant/advisor and speaker for Eli Lilly, Novo Nordisk and Sanofi, has attended advisory boards for Abbvie, Amgen, AstraZeneca, Biomea Fusion, Carmot/Roche, Sanofi, Zealand Pharma Regeneron, GSK and EktaH and as a speaker for AstraZeneca and Boehringer Ingelheim