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doi:10.1016/j.mehy.2012.07.034, PMID: 22951418 Marshall HE, Stamler JS (2001) Inhibition of NF-kappa B by S -nitrosylation

This is the second rejection for remestemcel-L, after the FDA first turned down Mesoblasts application in 2020, despite a 9-1 advisory committee vote in its favor

Earlier Phase 2 monotherapy work also studied higher weekly doses up to 4.5 mg, but the cagrilintide-only schedule above matches the 2.4 mg weekly target shown throughout this page