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3739 While it is encouraging that the weight loss achieved with GLP-1/GIPGLP-1 receptor agonists approaches levels typically seen after bariatric procedures such as gastric bypass or sleeve gastrectomy, the rapid regain of a significant portion of the lost weight after treatment discontinuation, accompanied by a reduction in lean body mass, raises new clinical concerns

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The medications are also given at levels much higher than natural GLP-1 ever reaches in the bloodstream By indiscriminately flooding the body with long-lasting molecules, the injections likely allow engineered GLP-1 drugs to penetrate parts of the body that the natural gut hormone cannot namely, deep in the brain." Semaglutides brain effects may explain why many people taking the drugs also lose the desire to engage in behaviors like drinking alcohol, shopping and smoking