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Li N, Alam J, Venkatesan MI, Eiguren-Fernandez A, Schmitz D, et al: Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals

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There are also other factors that may lead to a B6 deficiency, such as neglecting the meats, fruits, and vegetables that contain this vitamin and not taking supplements to make up for the deficit

However, translating those results into safe and effective human therapies requires well-designed clinical trials