When users report zero change in sleep quality after 7 consecutive nights at 100+ mcg, community protocols describe titrating the dose upward (to 200-300 mcg) before concluding it is ineffective
Invest 128 , 33413355 (2018)
Description Ingredients: Purified water, butylene glycol, beeswax, caprylic/capric triglyceride, niacinamide, cetearyl alcohol, isononyl isononanoate, arachidyl alcohol, 1,2-hexanediol, polyglyceryl-3 methylglucose distearate, behenyl alcohol, glyceryl stearate, betaine, arachidyl glucoside, allantoin, sorbitan oleate, panthenol, hydrogenated lecithin, tocopherol, xanthan gum, glycerin, Glutathione (600 ppm), ethylhexylglycerin, dipotassium glycyrrhizate, stearic acid, disodium EDTA, bisabolol, sodium hyaluronate, ascorbyl tetraisopalmitate, glucose, balm leaf extract, ladys mantle extract, yarrow extract, speedwell extract, peppermint leaf extract, evening primrose extract, polyglyceryl-10 stearate, ceramide NP, sodium ascorbyl phosphate, ceramide NS, cholesterol, phytosphingosine, ceramide AP, ceramide AS, sodium hydroxide, biotin, acetyl hexapeptide-8, copper tripeptide-1, pyridoxine, oligopeptide-29, oligopeptide-32, cyanocobalamine, palmitoyl pentapeptide-4, ceramide EP, riboflavin, beta-carotene, thiamine HCL, fragrance.
(PubMed) Holick MF, Matsuoka LY, Wortsman J
