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But as with any pharmaceutical breakthrough, an important question remains: What happens when we rely on an artificial version of a hormone the body is designed to produce itself

The STEP 4 trial led by Domenica Rubino showed that the effect depends on continuation: participants switched to placebo regained roughly two-thirds of their lost weight over the following year (Rubino et al., 2021)

This is generally temporary and resolves as weight stabilizes, but should be discussed with a healthcare provider if it persists beyond a few months

12 According to a KFF poll, only about 1 in 4 patients using GLP-1s reported that their insurance fully covered the cost