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In in vitro studies, saxagliptin and its active metabolite did not inhibit CYP1A2, 2A6, 2B6, 2C9, 2C19, 2D6, 2E1, or 3A4, or induce CYP1A2, 2B6, 2C9, or 3A4

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Novel pharmacological targets The neurokinin-1 receptor antagonist tradipitant was reported to improve nausea in gastroparesis, but the study was underpowered to show a benefit in the subgroup with diabetes [77]