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These factors limit absorption and systemic action [66]

Oral activity of the growth hormone releasing peptide His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 in rats, dogs and monkeys

Autophagic cell death involves the lysosomal degradation of cytoplasmic components, which can lead to cell death if the cell cannot recover from stress or nutrient deprivation [244]

Genetic analysis of AIP in 50 non-familial acromegalic patients resistant to treatment with SS analogs revealed a low, but non-negligible, prevalence of AIP germline mutations (62), suggesting a role for AIP alterations in SS-resistance of sporadic GH-secreting adenomas