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Opposite results were also found in isolated adult rat cardiomyocytes that contraction was not be accelerated after treated with GLP-1 (107), accompanied with a decreased left ventricular contractility (108)

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As the biosynthesis process depends on the addition of nitrogen sources, such as glycine and hypoxanthine, selection for strains resistant to the adenine antimetabolite, 4-aminopyrazolo (3, 4-d) pyrimidine, improved production (Park et al., 2007, 2011

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