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ATP and its degradation product adenosine are themselves neurotransmitter molecules (termed purinergic transmission) that can also modify the pre- or postsynaptic cells response if the appropriate receptors are present

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RETA treatment dramatically delayed LLC tumor onset, with unpalpable tumors in the RETA treated group until day 16, compared to onset observed in Veh treated mice where tumors were palpated starting on day 10 (Fig