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This form can be used directly in the body, without need for conversion, and is better utilised than cyanocobalamin (5)

The slightly higher number of AEs in the dosing conditions trial compared with the food-effect trial, particularly gastrointestinal AEs, may be explained by the difference in dosing regimen between the two trials

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In fact, the k cat / K m of SQOR toward H 2 S was estimated to be of the order of 10 7 M -1 s -1 ( 7 -fold higher than the rate constant for sulfide addition to disulfide in solution at pH 7.4 and 25 C (0.6 M -1 s -1 ) ( In the proposed catalytic cycle, sulfide first attacks the trisulfide bridge of the enzyme, generating persulfides at both Cys201 and Cys379